The wide variety of optoelectronics applications in NASA flight systems and instruments require that optoelectronic technologies meet the demanding requirements of the space environment throughout mission life. These requirements vary widely from intense radiation near Jupiter to the very cold temperatures on the Martian surface to the effects of solar flares in Earth orbit. Considerable work has been performed under the NEPP Program to meet these assurance needs and minimize the risk of insertion of optoelectronics in NASA systems. In this paper we provide recent examples of this work for a variety of NASA mission applications that employ various optoelectronic devices.